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48 µM), nucynta β1-adrenergic receptor, 5-HT2A receptor (IC50 values <1 µM), κand δ-ORs and M1 muscarinic receptor (Ki values <1 µM) . 43 µM), noradrenaline uptake nucynta transporter (Ki 0 . High affinity binding to several tapentadol wirkung tapentadol nzd tapentadol pdf tapentadol respiratory depression tapentadol for other receptors was observed, including σ2 receptor (Ki 0 .
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The functional role nucynta of 5-HT receptor pathways was unclear from the nonclinical data .
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Tapentadol induced dose-related analgesia in several mouse, rat, rabbit and dog models of acute, neuropathic and inflammatory pain, generally at extrapolated exposures (AUC) lower nucynta than that at the minimum recommended clinical dose .
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